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Table 1 Expression pattern of connexin and pannexin isoforms in vivo along the vascular tree. EC: endothelial cells; SMC: smooth muscle cells. ‘no’ indicates that a protein has yet to be identified in those size vessels, not that the protein is necessarily absent. Expression pattern varies between vascular beds

From: Pannexin channel and connexin hemichannel expression in vascular function and inflammation

Protein Large Arteries Resistance Arteries and Arterioles Capillaries Post-Capillary Venules and Venules Veins References
Endothelial Cell Expression
Cx32 only in isolated primary cell line only in isolated primary cell line no no (low levels in primary human cell lines) yes [43]
Cx37 yes yes yes downstream side of valved-veins and in some ECs of the wall of non-valved veins downstream side of valved-veins and in some ECs of the wall of non-valved veins [2830, 33, 3639]
Cx40 yes yes no no generally no [28, 29, 32, 33, 36, 37, 39]
Cx43 predominately areas of non-laminar flow yes yes upstream side of valved-veins and in some ECs of the wall of non-valved veins upstream side of valved-veins and in some ECs of the wall of non-valved veins [2830, 32, 33, 3539]
Cx45 yes no no no no [41, 42]
Cx47 no no no only subset of ECs that compose the valves only subset of ECs that compose the valves [38]
Panx1 yes yes yes yes no [35, 4446]
Panx2 yes yes no no no [44, 46]
Panx3 no <100 μm diameter no no no [44, 45]
Smooth Muscle Cell Expression
Cx32 no no   no no [43]
Cx37 yes yes   no yes [30, 33, 36, 37]
Cx40 no generally no   no no [32]
Cx43 yes yes   no yes [28, 30, 32, 33, 3537]
Cx45 yes yes   yes no [28, 33, 37, 42]
Cx47 no no   no no [38]
Panx1 no yes   yes no [4446]
Panx2 yes yes   no no [44, 46]
Panx3 no <100 μm diameter   no no [44, 45]