Fig. 2

Early gap junction structures determined by electron crystallography and modelling. a A 3D EM-derived map of a Cx43 GJC. b The densities at different positions show clearly the 24 TMs, four for each monomer. c Model of Cα atoms derived by Fleishman et al., [21], showing in yellow the residues identified as pore lining. Panel a-b adapted from Unger et al., [16]; Panel c adapted from Fleishman et al., [21]