Fig. 6From: Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expressionCell surface morphology and chromatin organization in wild type and mutant embryoid bodies. Wild type and mutant ES cells were cultured in suspension culture as embryoid bodies and treated with 1 μM RA for 5 days. Embryoid bodies were analyzed by transmission electron microscopy. a Representative images of the outer differentiated layer of cells. Arrows mark microvilli-containing endoderm cells. b Representative low magnification images of outer layer, presumably differentiated cells from wild type and mutant embryoid bodies. c Higher magnification images from two different nuclei for each cell line show the positioning of electron dense heterochromatin in relation to the inner nuclear membraneBack to article page