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Fig. 6 | BMC Cell Biology

Fig. 6

From: Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression

Fig. 6

Cell surface morphology and chromatin organization in wild type and mutant embryoid bodies. Wild type and mutant ES cells were cultured in suspension culture as embryoid bodies and treated with 1 μM RA for 5 days. Embryoid bodies were analyzed by transmission electron microscopy. a Representative images of the outer differentiated layer of cells. Arrows mark microvilli-containing endoderm cells. b Representative low magnification images of outer layer, presumably differentiated cells from wild type and mutant embryoid bodies. c Higher magnification images from two different nuclei for each cell line show the positioning of electron dense heterochromatin in relation to the inner nuclear membrane

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