TY - JOUR AU - Witt, R. AU - Weigand, A. AU - Boos, A. M. AU - Cai, A. AU - Dippold, D. AU - Boccaccini, A. R. AU - Schubert, D. W. AU - Hardt, M. AU - Lange, C. AU - Arkudas, A. AU - Horch, R. E. AU - Beier, J. P. PY - 2017 DA - 2017/02/28 TI - Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering JO - BMC Cell Biology SP - 15 VL - 18 IS - 1 AB - Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of lost muscle tissue by newly generating skeletal muscle combining different cell sources, such as myoblasts and mesenchymal stem cells (MSCs), within a three-dimensional matrix. Latest research showed that seeding skeletal muscle cells on aligned constructs enhance the formation of myotubes as well as cell alignment and may provide a further step towards the clinical application of engineered skeletal muscle. SN - 1471-2121 UR - https://doi.org/10.1186/s12860-017-0131-2 DO - 10.1186/s12860-017-0131-2 ID - Witt2017 ER -