Fig. 4

Genetic stability of DPPSC, before and after osteogenic differentiation by sCGH analysis. a, b sCGH from undifferentiated DPPSC at passages 1, 5, 10 and 15 (N = 6, XX and XY donors); a Fluorochromes image; b Fixed limits summary. c, d sCGH at day 21 of 2D osteogenic differentiation from DPPSC at passages 1, 5 and 10 (N = 3, XX and XY donors). c Fluorochromes image; d Fixed limits summary. e, f CGH from DPPSC (P10) at day 21 of osteogenic differentiation on biomaterials: Collagen and Titanium carriers (N = 2, XX donors). e Fluorochromes image; f Fixed limits summary. 47, XXY control samples (labeled in green) and DPPSC samples (labeled in red) were mixed and co-hybridized onto 12 (46, XY) metaphases in triplicate. A gain in the X or Y chromosome dosage was due to sex differences