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Fig. 6 | BMC Cell Biology

Fig. 6

From: Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide

Fig. 6

Relative mRNA gene expression of cell surface receptors in the presence of cRGDfC, w/ and w/o LIF. Supplementation of cRGDfC shut down the expression of RGD dependent integrin subunits, (a) alphaV and (b) beta 3, independent of LIF. The expression of (c) beta 1 and (d) E-Cadherin appeared to be LIF dependent. In the presence of LIF beta 1 and E-Cadherin expression was up-regulated and without LIF down-regulated. Mean ± SD, n = 3 independent experimental replicates. (***;p < 0.0001; **;p < 0.001; *;p < 0.05)

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