Fig. 9
From: Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1
Regulatory network elicited by nuclear translocation of syndecan-1 leading to inhibition of proliferation and survival. Data are based on differentially expressed genes obtained by microarray and transcription factor array on fibrosarcoma cells with preserved and impaired nuclear translocation of syndecan-1. Nuclear syndecan-1 activates several transcription factors (ovals) and induces immediate early genes. Transcription factors activate (arrows) or inhibit (bars) their targets, and in addition, they trigger the TGF-β pathway (rectangle). In turn, TGF-β can also induce EGR-1 and other transcription factors, which can provide a feedback loop. The arrows in blue represent the current knowledge about the role of target genes in governing different processes. The functional outcome of nuclear syndecan-1 signaling is the measured inhibition of proliferation and cell survival