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Table 3 Categories of top enriched pathways in transcriptomic datasets according to Gene Set Enrichment Analysis (GSEA)

From: Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1

Cell Cycle

SIZE

p-val

rank

 REACTOME_G1_S_TRANSITION

100

0.004

20

 REACTOME_MITOTIC_G1_G1_S_PHASES

124

0.01

30

 REACTOME_M_G1_TRANSITION

72

0.01

31

 REACTOME_S_PHASE

100

0.011

37

 REACTOME_CELL_CYCLE_CHECKPOINTS

105

0.015

43

 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION

22

0.022

62

 REACTOME_CELL_CYCLE

384

0.022

64

 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_

62

0.027

78

 REACTOME_G2_M_CHECKPOINTS

35

0.036

96

 REACTOME_MITOTIC_M_M_G1_PHASES

162

0.04

109

 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6

46

0.041

111

 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE

53

0.044

114

 BIOCARTA_EIF_PATHWAY

16

0.046

117

DNA synthesis and transcription

SIZE

p-val

rank

 REACTOME_RNA_POL_I_PROMOTER_OPENING

55

≤0.001

1

 REACTOME_SYNTHESIS_OF_DNA

84

0.003

16

 REACTOME_RNA_POL_I_TRANSCRIPTION

79

0.009

29

 REACTOME_DNA_STRAND_ELONGATION

30

0.013

42

 KEGG_DNA_REPLICATION

36

0.015

44

 REACTOME_DNA_REPLICATION

182

0.023

67

 REACTOME_RNA_POLI_RNA_POLIII_AND_MITOCH._TRANSCRIPTION

112

0.025

70

 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX

24

0.026

73

 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX

57

0.026

75

 REACTOME_TRANSCRIPTION

189

0.035

92

Immune System

SIZE

p-val

rank

 REACTOME_INTERFERON_SIGNALING

151

0.017

47

 BIOCARTA_CYTOKINE_PATHWAY

21

0.025

71

 BIOCARTA_TH1TH2_PATHWAY

18

0.026

72

 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B-CELL_RECEPTOR_BCR

92

0.03

83

 BIOCARTA_NKCELLS_PATHWAY

20

0.032

86

 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES

64

0.034

90

 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM

260

0.037

99

 BIOCARTA_DC_PATHWAY

22

0.044

115

 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

121

0.049

125

  1. The GSEA analysis was performed on the transcriptome of NLSdel versus Fls1. The significantly enriched pathways belong to three categories: cell cycle regulation, DNA synthesis and transcription, and immune responses