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Table 3 Categories of top enriched pathways in transcriptomic datasets according to Gene Set Enrichment Analysis (GSEA)

From: Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1

Cell Cycle SIZE p-val rank
 REACTOME_G1_S_TRANSITION 100 0.004 20
 REACTOME_MITOTIC_G1_G1_S_PHASES 124 0.01 30
 REACTOME_M_G1_TRANSITION 72 0.01 31
 REACTOME_S_PHASE 100 0.011 37
 REACTOME_CELL_CYCLE_CHECKPOINTS 105 0.015 43
 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION 22 0.022 62
 REACTOME_CELL_CYCLE 384 0.022 64
 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 62 0.027 78
 REACTOME_G2_M_CHECKPOINTS 35 0.036 96
 REACTOME_MITOTIC_M_M_G1_PHASES 162 0.04 109
 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 46 0.041 111
 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 53 0.044 114
 BIOCARTA_EIF_PATHWAY 16 0.046 117
DNA synthesis and transcription SIZE p-val rank
 REACTOME_RNA_POL_I_PROMOTER_OPENING 55 ≤0.001 1
 REACTOME_SYNTHESIS_OF_DNA 84 0.003 16
 REACTOME_RNA_POL_I_TRANSCRIPTION 79 0.009 29
 REACTOME_DNA_STRAND_ELONGATION 30 0.013 42
 KEGG_DNA_REPLICATION 36 0.015 44
 REACTOME_DNA_REPLICATION 182 0.023 67
 REACTOME_RNA_POLI_RNA_POLIII_AND_MITOCH._TRANSCRIPTION 112 0.025 70
 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 24 0.026 73
 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 57 0.026 75
 REACTOME_TRANSCRIPTION 189 0.035 92
Immune System SIZE p-val rank
 REACTOME_INTERFERON_SIGNALING 151 0.017 47
 BIOCARTA_CYTOKINE_PATHWAY 21 0.025 71
 BIOCARTA_TH1TH2_PATHWAY 18 0.026 72
 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B-CELL_RECEPTOR_BCR 92 0.03 83
 BIOCARTA_NKCELLS_PATHWAY 20 0.032 86
 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 64 0.034 90
 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 260 0.037 99
 BIOCARTA_DC_PATHWAY 22 0.044 115
 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 121 0.049 125
  1. The GSEA analysis was performed on the transcriptome of NLSdel versus Fls1. The significantly enriched pathways belong to three categories: cell cycle regulation, DNA synthesis and transcription, and immune responses