Fig. 3
From: Novel roles for scleraxis in regulating adult tenocyte function
Focal adhesion-related genes downregulated in tenocytes by exposure to scleraxis (Scx) siRNA. Heatmap showing normalized counts of differentially expressed genes related to focal adhesions or extracellular matrix-receptor interactions, clustered by relative Scx expression (as measured by qPCR) and expression pattern (a). Location, interactions, and downstream pathways of downregulated genes (b). Affected genes are shown in red and unaffected genes in black. Dashed lines indicate interactions between pathway components. COL4A2- collagen type IVα2, COL5A1- collagen type Vα1, COL6A2- collagen type VIα2, THBS4- thrombospondin 4, ITGA3- integrin subunit alpha 3, ITGB3- integrin subunit beta 3, HSPG2- heparin sulfate proteoglycan 2, LAMA5- laminin subunit alpha 5, LAMB2- laminin subunit beta 2, TLN1- talin 1, TLN2- talin 2, FLNB- filamin B, FLNC- filamin C, BCAR1- breast cancer anti-estrogen resistance protein 1, SHC3- SHC adaptor protein 3, SHC4- SHC adaptor protein 4, PPP1R12B- protein phosphatase 1 regulatory subunit 12B, PPP1R12C- protein phosphatase 1 regulatory subunit 12C, VCL- vinculin