Table 5 Gene Ontology (GO) analysis of differentially expressed genes
From: Novel roles for scleraxis in regulating adult tenocyte function
PANTHER GO-Slim Biological Process | Number of genes | Fold enrichment | FDR | |
|---|---|---|---|---|
Down-regulated | Cell-matrix adhesion (GO:0007160) | 6 | 4.79 | 3.7E-02 |
Protein folding (GO:0006457) | 9 | 4.00 | 1.8E-02 | |
Transmembrane receptor protein tyrosine kinase signaling (GO:0007169) | 11 | 2.77 | 4.6E-02 | |
Cytoskeleton organization (GO:0007010) | 24 | 2.33 | 6.8E-03 | |
Cell differentiation (GO:0030154) | 30 | 2.17 | 6.1E-03 | |
Regulation of phosphate metabolic process (GO:0019220) | 27 | 1.99 | 2.4E-02 | |
Organelle organization (GO:0006996) | 57 | 1.86 | 1.2E-03 | |
Developmental process (GO:0032502) | 64 | 1.63 | 6.8E-03 | |
Cellular component organization (GO:0016043) | 77 | 1.58 | 5.2E-03 | |
Phosphate-containing compound metabolic process (GO:0006796) | 64 | 1.53 | 2.3E-02 | |
Cellular component organization or biogenesis (GO:0071840) | 79 | 1.51 | 8.6E-03 | |
Nitrogen compound metabolic process (GO:0006807) | 91 | 1.39 | 3.1E-02 | |
Metabolic process (GO:0008152) | 195 | 1.29 | 3.2E-03 | |
Primary metabolic process (GO:0044238) | 153 | 1.26 | 3.7E-02 | |
Up-regulated | Oxidative phosphorylation (GO:0006119) | 5 | 6.64 | 2.0E-02 |
Mitochondrion organization (GO:0007005) | 8 | 5.00 | 8.9E-03 | |
Protein complex biogenesis (GO:0070271) | 13 | 3.37 | 9.0E-03 | |
Translation (GO:0006412) | 12 | 3.20 | 1.1E-02 | |
Protein complex assembly (GO:0006461) | 12 | 3.12 | 1.2E-02 | |
Transcription from RNA polymerase II promoter (GO:0006366) | 26 | 1.97 | 2.2E-02 | |
Cellular component biogenesis (GO:0044085) | 26 | 1.93 | 2.3E-02 | |
Cellular protein modification process (GO:0006464) | 26 | 1.91 | 2.4E-02 | |
Cell cycle (GO:0007049) | 23 | 1.89 | 4.5E-02 | |
Biosynthetic process (GO:0009058) | 55 | 1.78 | 3.5E-03 | |
Organelle organization (GO:0006996) | 35 | 1.68 | 3.1E-02 | |
Protein metabolic process (GO:0019538) | 44 | 1.65 | 2.2E-02 | |
Cellular component organization (GO:0016043) | 51 | 1.55 | 2.5E-02 | |
Cellular component organization or biogenesis (GO:0071840) | 53 | 1.50 | 3.3E-02 | |
Primary metabolic process (GO:0044238) | 113 | 1.37 | 9.7E-03 | |
Metabolic process (GO:0008152) | 137 | 1.34 | 5.7E-03 | |