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Fig. 4 | BMC Cell Biology

Fig. 4

From: Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

Fig. 4

G245C and R273H conferred cells stronger resistance to UV-induced apoptosis and attenuated cell cycle arrest. a Apoptosis degree induced by UV 30 J for 0 h and 12 h in cell lines. The data were presented as the portion of cells undergoing apoptosis tested by flow cytometry, the cells were dyed by PI and AnnexinV. b Quantitation of cell cycle arrest ratio in cells transfected by WT and mutant TP53 plasmids after UV 30 J for 0 h and 12 h treatment. Data was shown as the percentage of DNA amounts dyed by PI which was detected by flow cytometry. Data was shown as mean ± SE. (*P < 0.05, **P < 0.01, ***P < 0.001)

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