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Fig. 2 | BMC Cell Biology

Fig. 2

From: Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways

Fig. 2

Tan IIA inhibits cancer cell proliferation and migration. a-b The transwell assay was used to analyze the cell mobility. The number of migrated cells was recorded. Tan IIA at 1 μ M and 5 μ M were incubated with SW837 cells for 12 h. c-e qPCR assay for metastatic gene transcription. Compared to the control group, Tan IIA significantly increased the transcription of Rac1, CDC42, ROCK1. f-h The expression of adhesive factors were determined via western blotting. i-j EdU staining for cell proliferation. The number of EdU-positive cells was recorded. k-m Western blotting analysis for proliferation-related proteins. SW837 cells were treated with 1 μ M or 5 μ M Tan II for 12 h. *p < 0.05

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