Fig. 2

Removal of duplicated KIT copy by CRISPR/Cas9 from single allele with two KIT locus copies. a Schematic diagram of the strategy for removing the duplicated KIT copy when the KIT copy with the splice mutation is upstream of the normal KIT copy. b Schematic diagram of the strategy for removing the duplicated KIT copy when the KIT copy with the splice mutation is downstream of the normal KIT copy. Dashed line indicates that the length of the duplication region is 450 kb. DBP denotes the breakpoint of the duplication region. The red star indicates the splice mutation at the first nucleotide in intron 17 of the KIT gene