Fig. 4
From: Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus
Lamin A/C-Emerin co-depletion mislocalizes chromosome 19 territories. a Representative 3D-FISH images for CT18 (green) and CT19 (red) in control (untreated and siLacZ) cells, and single and co-depletion of Lamin A/C and Emerin. Scale bar ~ 10 μm. b-c Radial Distance (% R.D) distribution profiles for (b) CT18 and (c) CT19 in control (untreated and siLacZ) cells, and single and co-depletion of Lamin A/C and Emerin (X-axis: 0%: nuclear centre, 100%: nuclear periphery). Error bar: SEM, ** p < 0.01, n = number of CTs analysed, data compiled from N = 3 (N: number of independent biological replicates)