Fig. 2

Alignment of our FAK FERM structure with previously published avian and human structures. a Structural alignment of our high resolution FERM structure (6CB0 – blue) with published avian (2AL6 – green) and human (4NY0 – grey) FERM structures. Alignment was performed in PyMOL software. Note, key regions in our structure that show unique differences in electron density are highlighted in red. b Multiple sequence alignment of FAK FERM structures 6CB0, 2AL6, and 2NY0 performed with the Schrodinger multiple sequence viewer tool. Residue coloring is based on side chain chemistry. Key regions of extra electron density and non-conserved residues between human and avian sequences are boxed in red