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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

Fig. 3

Difference in Y397 region between our structure and previously published FERM structure. a Comparison of Y397 within FERM-kinase linker region between our structure (green) and PDB 2AL6 (cyan). 2Fo-Fc electron density map contoured at 1.0 σ is shown in mesh. Note, common ribbon structure between both proteins is shown in magenta. b Comparison of FERM F1 lobe residues nearby Y397 in our structure (green) and PDB 2AL6 (cyan). c Depiction of druggable pocket nearby Y397 in PDB 2AL6. Note, SiteScore = 0.9. d Depiction of region nearby Y397 in our FERM structure. Note, there is an absence of a discernible pocket and SiteMap did not identify this region as druggable

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