Fig. 3From: High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding siteDifference in Y397 region between our structure and previously published FERM structure. a Comparison of Y397 within FERM-kinase linker region between our structure (green) and PDB 2AL6 (cyan). 2Fo-Fc electron density map contoured at 1.0 σ is shown in mesh. Note, common ribbon structure between both proteins is shown in magenta. b Comparison of FERM F1 lobe residues nearby Y397 in our structure (green) and PDB 2AL6 (cyan). c Depiction of druggable pocket nearby Y397 in PDB 2AL6. Note, SiteScore = 0.9. d Depiction of region nearby Y397 in our FERM structure. Note, there is an absence of a discernible pocket and SiteMap did not identify this region as druggableBack to article page