Table 4 Marginal distributions (%) of amino acids by position relative to the S/T/Y/H-site

A

7

6.9

6.8

6.6

6.4

6.8

6.7

5.7

6.4

6.4

6.4

6.6

6.9

6.7

C

1.4

1.4

1.3

1.2

1.2

1.3

1.3

1.2

1.4

1.2

1.3

1.3

1.3

2.5

D

4.9

4.9

4.9

5

5

5.1

6.1

5.4

5.9

5.6

5.2

5.3

5.1

5.1

E

7.3

7.3

7

7.2

6.8

6.6

6

6.6

9.5

8.5

7.8

7.6

7.8

7.5

F

2.6

2.6

2.8

2.6

2.4

2.5

2.8

3.1

2.3

2.5

2.6

2.7

2.7

2.7

G

6.9

6.7

6.6

7.1

6.8

6.7

8.1

7.6

6.9

7.1

6.5

6.6

6.6

6.5

H

2.2

2.2

3.3

2.2

2.5

2.1

3.7

2

2

2.1

2.1

2.3

2.2

2.3

I

3.6

3.7

3.6

3.5

3.4

4.1

3.9

3.6

3.5

3.5

3.8

3.5

3.6

3.5

K

7.4

7.3

7

7.3

7.2

6.1

6

4.5

6

7.6

6.8

7.3

7.5

7.2

L

7.9

8.3

8.8

7.7

8

8

9.1

9.1

7.9

7.8

8.7

7.9

8

8.1

M

2.1

1.8

1.8

1.8

1.8

1.9

1.7

1.8

1.7

1.8

1.8

1.8

1.8

1.8

N

3.4

3.4

3.4

3.5

3.3

3.8

3.8

2.6

3.3

3.4

3.3

3.3

3.3

3.4

P

7.1

7

7

6.9

6.7

7.9

7.3

15.5

8

7.3

8.1

7.6

7.4

7

Q

4.5

4.4

4.3

4.8

4.1

4.4

3.8

4.6

3.9

4.3

4.2

4.3

4.4

4.3

R

7.4

7.5

7.7

7.3

11

7.3

6.8

5.1

6.1

6.8

6.4

6.9

7

7

S

10.6

10.7

10.3

11.7

10.9

11.7

9.8

9.2

11.6

11.1

11.3

10.6

10.8

10.5

T

5.7

5.5

5.3

5.4

5

5.7

4.4

4.1

5.9

5.1

5.7

5.5

5.6

5.5

V

5.2

5.2

5.2

5.1

4.8

5.4

5.5

5.3

5.2

5

5.3

5

5.3

5.1

W

0.8

0.7

0.7

0.7

0.6

0.6

0.6

0.8

0.5

0.7

0.7

0.7

0.7

0.8

Y

2.2

2.2

2.2

2.1

2

2.1

2.3

2.1

2

2.1

2.1

3.2

2.1

2.5