Skip to main content

Table 1 Dissociation constants (KD) of APC and PRK2 for the single PDZ2 and PDZ3 [12] domains as well as for the PDZ2/3 tandem domain of PTPN13

From: The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

Domain

KRHSGSYLVTSV (APC)

KD [μM]

 PDZ2

286 ± 21

 PDZ3

721 ± 148

 PDZ2 in PDZ2/3

211 ± 70

 PDZ3 in PDZ2/3

2574 ± 770

Domain

MFRDFDYIADWC (PRK2)

KD [μM]

 PDZ2

661 ± 71

 PDZ3

318 ± 47