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Table 1 Dissociation constants (KD) of APC and PRK2 for the single PDZ2 and PDZ3 [12] domains as well as for the PDZ2/3 tandem domain of PTPN13

From: The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated

Domain KRHSGSYLVTSV (APC)
KD [μM]
 PDZ2 286 ± 21
 PDZ3 721 ± 148
 PDZ2 in PDZ2/3 211 ± 70
 PDZ3 in PDZ2/3 2574 ± 770
Domain MFRDFDYIADWC (PRK2)
KD [μM]
 PDZ2 661 ± 71
 PDZ3 318 ± 47