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Fig. 5 | BMC Molecular and Cell Biology

Fig. 5

From: New STAT3-FOXL2 pathway and its function in cancer cells

Fig. 5

Summary of STAT3-FOXL2 signaling function in HeLa cell growth and apoptosis. Phosphorylated-STAT3 enters the cell nucleus from the cytoplasm and binds to the confirmed new binding sites, which are located in the promoter region of FOXL2, then up-regulates the expression of TNF, and down-regulates the expression of GnRHR and TRAIL. Finally, the cancer cell growth inhibition and apoptosis are inhibited

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