TY - JOUR AU - Petko, Jessica AU - Thileepan, Mathura AU - Sargen, Molly AU - Canfield, Victor AU - Levenson, Robert PY - 2019 DA - 2019/07/08 TI - Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions JO - BMC Molecular and Cell Biology SP - 22 VL - 20 IS - 1 AB - Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes. However, Wnt-independent functions of Wls are now being elucidated. Primates express an alternative splice variant of Wls (here termed WlsX). WlsX contains an alternatively spliced COOH-terminus, and does not appear to be able to sustain significant levels of WNT secretion because of its inability to undergo retrograde trafficking to the endoplasmic reticulum. The functional significance for this alternatively spliced form of Wls has not yet been elucidated. We previously identified a cohort of Wls interacting proteins using a combination of yeast 2-hybrid and candidate gene approaches. SN - 2661-8850 UR - https://doi.org/10.1186/s12860-019-0208-1 DO - 10.1186/s12860-019-0208-1 ID - Petko2019 ER -