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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Protective effect of silencing Stat1 on high glucose-induced podocytes injury via Forkhead transcription factor O1-regulated the oxidative stress response

Fig. 3

High glucose affects the protein expression of apoptosis related, Stat1 and FoxO1 in MPC-5 cells. The experiments were divided into three groups, which were control (5.5 mmol/L normal glucose), NM (5.5 mmol/L glucose+ 24.5 mmol/L mannitol) and HG (30 mmol/L glucose). a The cleaved caspased-3, Bcl-2, Bax, Stat1 and FoxO1 protein levels were detected by western blot in MPC-5 cells. b Relative protein expression of cleaved caspased-3 showed as bar diagrams. c Relative protein expression of Bcl-2 showed as bar diagrams. d Relative protein expression of Bax showed as bar diagrams. e Relative protein expression of Stat1 showed as bar diagrams. f Relative protein expression of FoxO1 showed as bar diagrams. GAPDH served as an internal control. Data were expressed as mean ± SD from three independent experiments. (*Compared with control, *P < 0.05, **P < 0.01)

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