Table 3 Hazard ratios and 95% confidence interval for the association of LCA-derived metabolic classes and overall cancer risk and cancer specific risk
From: Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis
| Â | Hazard Ratios (95% CI) a | Hazard Ratios (95% CI) b |
|---|---|---|
Cancer Risk: All cancer types | ||
 Number of events | 1956 | 1956 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.09 (0.98–1.22) | 1.05 (0.94–1.17) |
  3 - Liver | 1.28 (1.10–1.50) | 1.28 (1.09–1.49) |
  4 – Inflammation & Iron | 1.17 (0.97–1.41) | 1.17 (0.97–1.41) |
Cancer Risk: Buccal cavity and pharynx | ||
 Number of events | 34 | 34 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.79 (0.77–4.14) | 1.70 (0.73–1.17) |
  3 - Liver | 2.66 (0.96–7.35) | 2.60 (0.94–7.16) |
  4 - Inflammation & Iron | 3.94 (1.38–11.30) | 3.77 (1.31–10.82) |
Cancer Risk: Digestive organs and peritoneum | ||
 Number of events | 133 | 133 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 0.83 (0.62–1.11) | 0.83 (0.62–1.11) |
  3 - Liver | 2.12 (1.54–2.91) | 2.12 (1.54–2.91) |
  4 - Inflammation & Iron | 0.86 (0.51–1.46) | 0.86 (0.51–1.46) |
Cancer Risk: Respiratory system | ||
 Number of events | 133 | 133 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.40 (0.94–2.08) | 1.32 (0.88–1.96) |
  3 - Liver | 0.90 (0.44–1.82) | 0.87 (0.43–1.77) |
  4 - Inflammation & Iron | 1.48 (0.76–2.88) | 1.46 (0.75–2.84) |
Cancer Risk: Skin melanoma | ||
 Number of events | 205 | 205 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 0.78 (0.56–1.10) | 0.78 (0.56–1.11) |
  3 - Liver | 0.71 (0.40–1.26) | 0.73 (0.41–1.31) |
  4 - Inflammation & Iron | 0.70 (0.35–1.37) | 0.70 (0.35–1.37) |
Cancer Risk: Breast and genito-urinary organs | ||
 Number of events | 655 | 655 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.19 (0.99–1.42) | 1.12 (0.94–1.33) |
  3 - Liver | 1.04 (0.80–1.37) | 1.04 (0.80–1.37) |
  4 - Inflammation & Iron | 1.25 (0.91–1.71) | 1.25 (0.91–1.71) |
Cancer Risk: Brain & nervous system, Thyroids | ||
 Number of events | 34 | 34 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.01 (0.51–1.99) | 0.96 (0.48–1.00) |
  3 - Liver | 1.01 (0.38–2.67) | 0.99 (0.38–2.59) |
  4 - Inflammation & Iron | 0.92 (0.28–2.99) | 0.91 (0.28–2.96) |
Cancer Risk: Connective and endocrine tissue | ||
 Number of events | 56 | 56 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 0.65 (0.21–1.95) | 0.64 (0.21–1.94) |
  3 - Liver | 2.65 (1.00–7.02) | 2.67 (1.01–7.07) |
  4 - Inflammation & Iron | 3.00 (1.11–8.11) | 2.96 (1.10–8.00) |
Cancer Risk: Lymphatic and hematopoietic tissues: Hodgkin lymphoma, Non-H lymphoma, Leukemia and Myeloma | ||
 Number of events | 129 | 129 |
  1 - Normal class | 1.00 (ref) | 1.00 (ref) |
  2 - Lipids | 1.72 (1.15–2.56) | 1.68 (1.12–2.51) |
  3 - Liver | 1.65 (0.91–3.00) | 1.68 (0.93–3.05) |
  4 - Inflammation & Iron | 1.23 (0.56–2.68) | 1.25 (0.57–2.73) |