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Table 3 Hazard ratios and 95% confidence interval for the association of LCA-derived metabolic classes and overall cancer risk and cancer specific risk

From: Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis

  Hazard Ratios (95% CI) a Hazard Ratios (95% CI) b
Cancer Risk: All cancer types
 Number of events 1956 1956
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.09 (0.98–1.22) 1.05 (0.94–1.17)
  3 - Liver 1.28 (1.10–1.50) 1.28 (1.09–1.49)
  4 – Inflammation & Iron 1.17 (0.97–1.41) 1.17 (0.97–1.41)
Cancer Risk: Buccal cavity and pharynx
 Number of events 34 34
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.79 (0.77–4.14) 1.70 (0.73–1.17)
  3 - Liver 2.66 (0.96–7.35) 2.60 (0.94–7.16)
  4 - Inflammation & Iron 3.94 (1.38–11.30) 3.77 (1.31–10.82)
Cancer Risk: Digestive organs and peritoneum
 Number of events 133 133
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 0.83 (0.62–1.11) 0.83 (0.62–1.11)
  3 - Liver 2.12 (1.54–2.91) 2.12 (1.54–2.91)
  4 - Inflammation & Iron 0.86 (0.51–1.46) 0.86 (0.51–1.46)
Cancer Risk: Respiratory system
 Number of events 133 133
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.40 (0.94–2.08) 1.32 (0.88–1.96)
  3 - Liver 0.90 (0.44–1.82) 0.87 (0.43–1.77)
  4 - Inflammation & Iron 1.48 (0.76–2.88) 1.46 (0.75–2.84)
Cancer Risk: Skin melanoma
 Number of events 205 205
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 0.78 (0.56–1.10) 0.78 (0.56–1.11)
  3 - Liver 0.71 (0.40–1.26) 0.73 (0.41–1.31)
  4 - Inflammation & Iron 0.70 (0.35–1.37) 0.70 (0.35–1.37)
Cancer Risk: Breast and genito-urinary organs
 Number of events 655 655
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.19 (0.99–1.42) 1.12 (0.94–1.33)
  3 - Liver 1.04 (0.80–1.37) 1.04 (0.80–1.37)
  4 - Inflammation & Iron 1.25 (0.91–1.71) 1.25 (0.91–1.71)
Cancer Risk: Brain & nervous system, Thyroids
 Number of events 34 34
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.01 (0.51–1.99) 0.96 (0.48–1.00)
  3 - Liver 1.01 (0.38–2.67) 0.99 (0.38–2.59)
  4 - Inflammation & Iron 0.92 (0.28–2.99) 0.91 (0.28–2.96)
Cancer Risk: Connective and endocrine tissue
 Number of events 56 56
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 0.65 (0.21–1.95) 0.64 (0.21–1.94)
  3 - Liver 2.65 (1.00–7.02) 2.67 (1.01–7.07)
  4 - Inflammation & Iron 3.00 (1.11–8.11) 2.96 (1.10–8.00)
Cancer Risk: Lymphatic and hematopoietic tissues: Hodgkin lymphoma, Non-H lymphoma, Leukemia and Myeloma
 Number of events 129 129
  1 - Normal class 1.00 (ref) 1.00 (ref)
  2 - Lipids 1.72 (1.15–2.56) 1.68 (1.12–2.51)
  3 - Liver 1.65 (0.91–3.00) 1.68 (0.93–3.05)
  4 - Inflammation & Iron 1.23 (0.56–2.68) 1.25 (0.57–2.73)
  1. aTime scale adjusted for age, sex and CCI.
  2. bAge scale adjusted for age, sex and CCI.