Fig. 9
From: Improved homology modeling of the human & rat EP4 prostanoid receptors
a Overlay of endogenous ligands PGE2 (green), PGE1 (teal), 11-deoxy-PGE1 (pink), 11-deoxy-PGE2 (yellow) docked on hEP4 receptor. SiteMap hot spot points shown as spheres, indicating shape of binding pocket. b Overlay of lead agonists Sulprostone (orange) CAY10684 (teal), Rivenprost (pink), PGE2 (green) docked on hEP4 receptor. SiteMap hot spot points are shown as spheres which indicate the shape of the binding pocket