Fig. 1From: CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switchesa and b: (a) ABBV-323 strongly inhibits CD40 signaling in B cells (inhibition of CD86 expression) without inducing agonist activity (stimulation of CD86 expression). To measure antagonist activity, CD40L+ jurkat cells were used to stimulate primary human B cells +/− ABBV-323. (b) To measure agonist activity, B cells were incubated with anti-CD40 antibodiesBack to article page