Fig.8
From: CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
a and b (a) ABBV-323 Fab (blue) bound to crystallographic CD40 dimer (second monomer shown in green ribbon) which shows interaction with LCDR1 R32. (b) FAB516 Fab (orange) bound to crystallographic CD40 dimer (second monomer shown in green ribbon) which shows no interaction with LCDR1 L32. N and C termini are also labeled to demonstrate the antiparallel dimers for both ABBV-323 and FAB516