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Table 1 Measuring agonist and antagonist activities of several CD40 antibody variants

From: CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

Antibody variants VL LCDR1 Sequence
(KSSQSLLNSGNQKNYLT)
Blocking of CD40L Agonist: huCD40 reporter assay IC50 nM Antagonist: Jurkat/ Reporter assay IC50 nM
ABBV-323 KSSQSLLNRGNQKNYLT Yes No 3.1
FAB518 KSSQSLLNPGNQKNYLT Yes 62 No
FAB516 KSSQSLLNLGNQKNYLT Yes 157 No