Table 1 Measuring agonist and antagonist activities of several CD40 antibody variants
From: CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches
Antibody variants | VL LCDR1 Sequence (KSSQSLLNSGNQKNYLT) | Blocking of CD40L | Agonist: huCD40 reporter assay IC50 nM | Antagonist: Jurkat/ Reporter assay IC50 nM |
|---|---|---|---|---|
ABBV-323 | KSSQSLLNRGNQKNYLT | Yes | No | 3.1 |
FAB518 | KSSQSLLNPGNQKNYLT | Yes | 62 | No |
FAB516 | KSSQSLLNLGNQKNYLT | Yes | 157 | No |