CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches

Table 3 Protein quality characterization

Protein name	Isotype		Monomer % by SEC	Endotoxin level^a	Mass Spec. Identity^b
Protein name	Heavy chain	Light chain	Monomer % by SEC	Endotoxin level^a	Mass Spec. Identity^b
FAB518	hCg1_z,non-a	Kappa	100	< 0.1 EU/mg	Consistent
FAB516	hCg1_z,non-a	Kappa	100	< 0.1 EU/mg	Consistent
CP 870,893	hCg1_z,non-a	Kappa	99	< 0.1 EU/mg	Consistent
ABBV-323	hCg1_z,non-a	Kappa	100	< 0.4 EU/mg	Consistent

^aEndotoxin levels assessed by PTS EndoSafe LAL
^bExpected (theoretical) molecular weight (MW) is consistent with measured MW by Mass Spec

ISSN: 2661-8850