Table 4 The top ten significantly enriched pathways of targeted ribosomal proteins in the predicted PPI, based on DAVID and KOBAS analysis
From: In silico evidence of de novo interactions between ribosomal and Epstein - Barr virus proteins
Platform | Pathway database | Pathway names | p-value |
|---|---|---|---|
DAVID | KEGG | Ribosome | 2.68e-43 |
Reactome | 3′ -UTR-mediated translational regulation | 2.07e-41 | |
Reactome | Influenza Infection | 8.22e-37 | |
Reactome | Metabolism of proteins | 6.79e-33 | |
Reactome | Gene Expression | 3.96e-27 | |
Reactome | APC-Cdc20 mediated degradation of Nek2A | 0.002563 | |
Reactome | Regulation of activated PAK-2p34 by proteasome mediated degradation | 0.014244 | |
Reactome | Signaling by EGFR | 0.014717 | |
Reactome | APC/C: Cdh1-mediated degradation of Skp2 | 0.026468 | |
Reactome | Signaling by Wnt | 0.026468 | |
KOBAS | Reactome | Viral mRNA Translation | 4.96e-55 |
Reactome | Peptide chain elongation | 4.96e-55 | |
Reactome | Selenocysteine synthesis | 5.58e-55 | |
Reactome | Eukaryotic Translation Elongation | 6.99e-55 | |
Reactome | Eukaryotic Translation Termination | 7.83e-55 | |
Reactome | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 1.26e-54 | |
Reactome | Formation of a pool of free 40S subunits | 2.05e-54 | |
Reactome | L13a-mediated translational silencing of Ceruloplasmin expression | 1.50e-53 | |
Reactome | GTP hydrolysis and joining of the 60S ribosomal subunit | 1.61e-53 | |
Reactome | Nonsense-Mediated Decay (NMD) | 3.61e-53 |