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Fig. 6 | BMC Molecular and Cell Biology

Fig. 6

From: lncRNA H19 promotes matrix mineralization through up-regulating IGF1 by sponging miR-185-5p in osteoblasts

Fig. 6

Schematic diagram of proposed mechanism. lncRNA H19 promoted matrix mineralization of osteoblasts through miR-185-5p/IGF1 axis. In mineralization condition, H19 is up-regulated and sponge miR-185-5p. The decreased in miR-185-5p availability, increases the level and translation of IGF1 mRNA, which in turn up-regulates the expression of OCN, ALP and Col1agen I involved in bone matrix mineralization. By contrast, when miR-185-5p is up-regulated, because H19 is decreased, the level of IGF1 is diminished and subsequent inhibition of mineralization, with arrows indicating the process

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BMC Molecular and Cell Biology

ISSN: 2661-8850

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