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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: DUF3669, a “domain of unknown function” within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression

Fig. 1

Compilation of amino acid sequence logos for DUF3669 domain-encoding genes from mammals, birds and reptiles. The x-axis indicates the position within the domain and the y-axis denotes the information content (bits) for each amino acid. The height represents the frequency of each amino acid at a certain position within the tested sequence set. The overall DUF3669 consensus sequence at the top was derived from all DUF3669-containing proteins identified in amniotes (n = 538. The other DUF3669 domain logos represent the ortholog groups of six of the seven human DUF3669-encoding KRAB-ZNFs (ZNF212 n = 49; ZNF282 n = 99; ZNF398 n = 31; ZNF746 n = 59; ZNF777 n = 90; ZNF783 n = 33) and proteins that could not unequivocally attributed to any human ortholog group (“unassigned proteins”; n = 176). ZNF767 was only found as a single human pseudogene and is not depicted here. See Additional file 1 for a complete compilation

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