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Table 1 Isolated antigen HER2 recognition in the ELISA test to assess the mAb folding without chains physical separation

From: Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

Molecule

Trastuzumab

Denatured trastuzumab

Renatured trastuzumab

Isolated antigen HER2 recognition

51 ± 5 AU/μg

ND

22 ± 1 AU/μg