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Table 1 Viral antigens and viral DNA in HepG2.2.15 cell culture supernatant after transfection

From: Minicircle DNA vector expressing interferon-lambda-3 inhibits hepatitis B virus replication and expression in hepatocyte-derived cell line

 

Time Points

Group

P-value

Control (1)

MC.IFNα (2)

MC.IFNλ3 (3)

2 vs.1

3 vs.1

3 vs.2

HBsAg (IU/mL)

day 3

403.3 ± 26.2

261.4 ± 36.1

303.3 ± 20.6

**

**

ns

day 6

456.4 ± 45.1

382.5 ± 5.8

288.9 ± 50.9

*

**

*

HBeAg (S/CO)

day 3

187.6 ± 10.7

122.8 ± 12.1

137.9 ± 9.4

**

**

ns

day 6

253.4 ± 30.4

200.2 ± 5.3

152.2 ± 20.7

*

**

*

HBV DNA (100%)

day 3

1.00 ± 0.017

0.436 ± 0.034

0.536 ± 0.020

**

**

ns

day 6

1.01 ± 0.005

0.50 ± 0.03

0.34 ± 0.03

**

**

*

  1. ** indicates P < 0.01; * indicates P < 0.05; ns represents not significant (P > 0.05). Group 1, 2 and 3 represent Control, MC.IFNα and MC.IFNλ3 group, respectively