Skip to main content
Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Identification of universal and cell-type specific p53 DNA binding

Fig. 1

Stereotyped p53 binding across 12 cell lines. (A) ChIP-seq for p53 in 12 p53 wild-type cell lines. UCSC screen shots of p53 binding sites for three canonical p53 target genes are shown. (B) Motif analysis recovered a p53 motif that was centrally enriched within peaks. (C) Heatmap showing p53 binding intensity in 8742 locations in the genome. Cell lines were clustered on p53 binding and resulted in lineages clustering together. (D) Comparison of p53 binding in two cancer cell lines (UACC62 and UACC257) as well as between one cancer (UACC257) and one non-cancerous cell line (RPE1). (E) Comparison of p53 binding between Nutlin3A and IR treated samples in MCF7 or UACC257 cells

Back to article page