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Fig. 2 | BMC Molecular and Cell Biology

Fig. 2

From: Identification of universal and cell-type specific p53 DNA binding

Fig. 2

Genomic sequence is weakly predictive of p53 binding. (A) The correlation between motif strength and p53 binding is shown as a function of the number of cell lines across which the peak height was averaged, box plots represent the distribution of correlations across all possible cell line combinations. (B) The degree to which p53 binding motif predicts the strength of p53 binding is shown in a box plot, with p53 binding sites binned by their motif strength. (C) The top enriched motif identified by in vitro ChIP. (D) UCSC screenshots of p53 binding sites in A549, UO31 and UACC257 in response to IR, motif score, and in vitro p53 binding signal are shown for CDKN1A/p21, MDM2, and MDM4. (E) In vivo p53 binding strength is shown in a box plot, binned by in vitro p53 binding signal at each genomic site

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