Fig. 3

Variable p53 binding sites show cell-type specific functional enrichment. (A) Scatterplot of all 8742 p53 binding sites in response to 4Gy IR by their average ChIP signal and coefficient of variation (CV). Highlighted in red are ‘highly variable’ peaks defined as having higher than expected CV relative to the peak height. Example binding sites are labeled with the associated gene names. (B) UCSC screen shots of four example ‘variable’ peaks. (C) Heatmap of ‘variable’ p53 peaks that are also nearby (< 10 kb) transcription start sites of genes. The intensity of each peak is normalized to the average across 12 cell lines. Cell lines and peaks were hierarchically clustered, with no grouping by lineage observed for cell lines. Groups of inflammatory and the ER associated are highlighted