TY - STD TI - Stayton C, et al. Cloning and characterization of a new human Xq13 gene, encoding a putative helicase. Hum Mol Genet. 1994;3:1957–202197d0a00c-cd1e-70b9-d02b-07dfd7fb2b35. ID - ref1 ER - TY - STD TI - Gibbons RJ, Picketts DJ, Villard L, Higgs DR. Mutations in a putative global transcriptional regulator cause X-linked mental retardation with α-thalassemia (ATR-X syndrome). Cell. 1995;80(6):837–45. ID - ref2 ER - TY - JOUR AU - Picketts, D. J. AU - Tastan, A. O. AU - Higgs, D. R. AU - Gibbons, R. J. PY - 1998 DA - 1998// TI - Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains JO - Mamm Genome VL - 9 UR - https://doi.org/10.1007/s003359900781 DO - 10.1007/s003359900781 ID - Picketts1998 ER - TY - JOUR AU - Lee, N. G. AU - Hong, Y. K. AU - Yu, S. Y. AU - Han, S. Y. AU - Geum, D. AU - Cho, K. S. PY - 2007 DA - 2007// TI - dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation JO - FEBS Lett VL - 581 UR - https://doi.org/10.1016/j.febslet.2007.05.005 DO - 10.1016/j.febslet.2007.05.005 ID - Lee2007 ER - TY - JOUR AU - Argentaro, A. PY - 2007 DA - 2007// TI - Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX JO - Proc Natl Acad Sci VL - 104 UR - https://doi.org/10.1073/pnas.0704057104 DO - 10.1073/pnas.0704057104 ID - Argentaro2007 ER - TY - JOUR AU - Eustermann, S. PY - 2011 DA - 2011// TI - Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin JO - Nat Struct Mol Biol VL - 18 UR - https://doi.org/10.1038/nsmb.2070 DO - 10.1038/nsmb.2070 ID - Eustermann2011 ER - TY - JOUR AU - McDowell, T. L. PY - 1999 DA - 1999// TI - Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes JO - Proc Natl Acad Sci VL - 96 UR - https://doi.org/10.1073/pnas.96.24.13983 DO - 10.1073/pnas.96.24.13983 ID - McDowell1999 ER - TY - JOUR AU - Lu, H. -. C. PY - 2018 DA - 2018// TI - Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST JO - Oncotarget VL - 9 UR - https://doi.org/10.18632/oncotarget.25195 DO - 10.18632/oncotarget.25195 ID - Lu2018 ER - TY - JOUR AU - Jiao, Y. PY - 2011 DA - 2011// TI - DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors JO - Science VL - 331 UR - https://doi.org/10.1126/science.1200609 DO - 10.1126/science.1200609 ID - Jiao2011 ER - TY - JOUR AU - Heaphy, C. M. PY - 2011 DA - 2011// TI - Altered telomeres in tumors with ATRX and DAXX mutations JO - Science VL - 333 UR - https://doi.org/10.1126/science.1207313 DO - 10.1126/science.1207313 ID - Heaphy2011 ER - TY - JOUR AU - Molenaar, J. J. PY - 2012 DA - 2012// TI - Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes JO - Nature VL - 483 UR - https://doi.org/10.1038/nature10910 DO - 10.1038/nature10910 ID - Molenaar2012 ER - TY - JOUR AU - Clynes, D. PY - 2015 DA - 2015// TI - Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX JO - Nat Commun VL - 6 UR - https://doi.org/10.1038/ncomms8538 DO - 10.1038/ncomms8538 ID - Clynes2015 ER - TY - JOUR AU - Berubé, N. G. AU - Jagla, M. AU - Smeenk, C. AU - Repentigny, Y. AU - Kothary, R. AU - Picketts, D. J. PY - 2002 DA - 2002// TI - Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice JO - Hum Mol Genet VL - 11 UR - https://doi.org/10.1093/hmg/11.3.253 DO - 10.1093/hmg/11.3.253 ID - Berubé2002 ER - TY - JOUR AU - Alekseyenko, A. A. AU - Gorchakov, A. A. AU - Zee, B. M. AU - Fuchs, S. M. AU - Kharchenko, P. V. AU - Kuroda, M. I. PY - 2014 DA - 2014// TI - Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs JO - Genes Dev VL - 28 UR - https://doi.org/10.1101/gad.241950.114 DO - 10.1101/gad.241950.114 ID - Alekseyenko2014 ER - TY - JOUR AU - López-Falcón, B. PY - 2014 DA - 2014// TI - Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-linked (ATRX) vertebrate protein JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0113182 DO - 10.1371/journal.pone.0113182 ID - López-Falcón2014 ER - TY - JOUR AU - Chavez, J. PY - 2017 DA - 2017// TI - dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres JO - Chromosoma VL - 126 UR - https://doi.org/10.1007/s00412-017-0634-9 DO - 10.1007/s00412-017-0634-9 ID - Chavez2017 ER - TY - JOUR AU - Lee, E. Y. H. P. AU - Muller, W. J. PY - 2010 DA - 2010// TI - Gout Breast Cancer: Oncogenes and tumor suppressor genes JO - Cold Spring Harb Perspect Biol VL - 2 UR - https://doi.org/10.1101/cshperspect.a003236 DO - 10.1101/cshperspect.a003236 ID - Lee2010 ER - TY - JOUR AU - Danussi, C. PY - 2018 DA - 2018// TI - Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-018-03476-6 DO - 10.1038/s41467-018-03476-6 ID - Danussi2018 ER - TY - JOUR AU - Hampton, T. A. PY - 2000 DA - 2000// TI - SEREX analysis for tumor antigen identification in a mouse model of adenocarcinoma JO - Cancer Gene Ther VL - 7 UR - https://doi.org/10.1038/sj.cgt.7700124 DO - 10.1038/sj.cgt.7700124 ID - Hampton2000 ER - TY - JOUR AU - Mukherjee, J. PY - 2018 DA - 2018// TI - Mutant IDH1 cooperates with ATRX loss to drive the alternative lengthening of telomere phenotype in glioma JO - Cancer Res VL - 78 UR - https://doi.org/10.1158/0008-5472.CAN-17-2269 DO - 10.1158/0008-5472.CAN-17-2269 ID - Mukherjee2018 ER - TY - JOUR AU - Singhi, A. D. PY - 2017 DA - 2017// TI - Alternative lengthening of telomeres and loss of DAXX/ATRX expression predicts metastatic disease and poor survival in patients with pancreatic neuroendocrine tumors JO - Clin Cancer Res VL - 23 UR - https://doi.org/10.1158/1078-0432.CCR-16-1113 DO - 10.1158/1078-0432.CCR-16-1113 ID - Singhi2017 ER - TY - STD TI - Campbell PJ, Forbes Simon A, Beare D, Boutselakis H, Bamford S, Bindal N, Tate J, Cole CG, Ward S, Dawson E, Ponting L, Stefancsik R, Harsha B, Kok CY, Jia M, Jubb H, Sondka Z, Thompso S. COSMIC: somatic cancer genetics at high-resolution. Nucleic Acids Res. 2016;45(D1):D777–83. ID - ref22 ER - TY - JOUR AU - Uhlén, M. PY - 2015 DA - 2015// TI - Tissue-based map of the human proteome JO - Science VL - 347 UR - https://doi.org/10.1126/science.1260419 DO - 10.1126/science.1260419 ID - Uhlén2015 ER - TY - JOUR AU - Lewis, P. W. AU - Elsaesser, S. J. AU - Noh, K. -. M. AU - Stadler, S. C. AU - Allis, C. D. PY - 2010 DA - 2010// TI - Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres JO - Proc Natl Acad Sci VL - 107 UR - https://doi.org/10.1073/pnas.1008850107 DO - 10.1073/pnas.1008850107 ID - Lewis2010 ER - TY - JOUR AU - Voon, H. P. J. PY - 2015 DA - 2015// TI - ATRX plays a key role in maintaining silencing at interstitial heterochromatic loci and imprinted genes JO - Cell Rep VL - 11 UR - https://doi.org/10.1016/j.celrep.2015.03.036 DO - 10.1016/j.celrep.2015.03.036 ID - Voon2015 ER - TY - JOUR AU - Eissenberg, J. C. AU - Elgin, S. C. PY - 2000 DA - 2000// TI - The {HP1} protein family: getting a grip on chromation JO - Curr Opin Genet Dev VL - 10 UR - https://doi.org/10.1016/S0959-437X(00)00058-7 DO - 10.1016/S0959-437X(00)00058-7 ID - Eissenberg2000 ER - TY - JOUR AU - Swenson, J. M. AU - Colmenares, S. U. AU - Strom, A. R. AU - Costes, S. V. AU - Karpen, G. H. PY - 2016 DA - 2016// TI - The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic JO - Elife VL - 5 UR - https://doi.org/10.7554/eLife.16096 DO - 10.7554/eLife.16096 ID - Swenson2016 ER - TY - JOUR AU - Schotta, G. PY - 2002 DA - 2002// TI - Central role of Drosophila SU (VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing JO - EMBO J VL - 21 UR - https://doi.org/10.1093/emboj/21.5.1121 DO - 10.1093/emboj/21.5.1121 ID - Schotta2002 ER - TY - BOOK AU - Rudolph, T. PY - 2007 DA - 2007// TI - Heterochromatin Formation in Drosophila Is Initiated through Active Removal of H3K4 ID - Rudolph2007 ER - TY - JOUR AU - Wood, J. G. PY - 2010 DA - 2010// TI - Chromatin remodeling in the aging genome of Drosophila JO - Aging Cell VL - 9 UR - https://doi.org/10.1111/j.1474-9726.2010.00624.x DO - 10.1111/j.1474-9726.2010.00624.x ID - Wood2010 ER - TY - JOUR AU - Cryderman, D. E. AU - Vitalini, M. W. AU - Wallrath, L. L. PY - 2011 DA - 2011// TI - Heterochromatin protein 1a is required for an open chromatin structure JO - Transcription VL - 2 UR - https://doi.org/10.4161/trns.2.2.14687 DO - 10.4161/trns.2.2.14687 ID - Cryderman2011 ER - TY - JOUR AU - Greil, F. PY - 2003 DA - 2003// TI - Distinct HP1 and Su (var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location JO - Genes Dev VL - 17 UR - https://doi.org/10.1101/gad.281503 DO - 10.1101/gad.281503 ID - Greil2003 ER - TY - JOUR AU - Fanti, L. AU - Berloco, M. AU - Piacentini, L. AU - Pimpinelli, S. PY - 2003 DA - 2003// TI - Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites JO - Genetica VL - 117 UR - https://doi.org/10.1023/A:1022971407290 DO - 10.1023/A:1022971407290 ID - Fanti2003 ER - TY - JOUR AU - Lu, B. Y. AU - Emtage, P. C. AU - Duyf, B. J. AU - Hilliker, A. J. AU - Eissenberg, J. C. PY - 2000 DA - 2000// TI - Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila JO - Genetics VL - 155 ID - Lu2000 ER - TY - JOUR AU - Penke, T. J. R. AU - McKay, D. J. AU - Strahl, B. D. AU - Gregory Matera, A. AU - Duronio, R. J. PY - 2016 DA - 2016// TI - Direct interrogation of the role of H3K9 in metazoan heterochromatin function JO - Genes Dev VL - 30 UR - https://doi.org/10.1101/gad.286278.116 DO - 10.1101/gad.286278.116 ID - Penke2016 ER - TY - JOUR AU - Hallson, G. PY - 2008 DA - 2008// TI - The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein JO - Proc Natl Acad Sci VL - 105 UR - https://doi.org/10.1073/pnas.0801698105 DO - 10.1073/pnas.0801698105 ID - Hallson2008 ER - TY - JOUR AU - Eissenberg, J. C. AU - James, T. C. AU - Foster-Hartnett, D. M. AU - Hartnett, T. AU - Ngan, V. AU - Elgin, S. C. PY - 1990 DA - 1990// TI - Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster JO - Proc Natl Acad Sci U S A VL - 87 UR - https://doi.org/10.1073/pnas.87.24.9923 DO - 10.1073/pnas.87.24.9923 ID - Eissenberg1990 ER - TY - JOUR AU - Eissenberg, J. C. AU - Elgin, S. C. R. PY - 2014 DA - 2014// TI - HP1a: a structural chromosomal protein regulating transcription JO - Trends Genet VL - 30 UR - https://doi.org/10.1016/j.tig.2014.01.002 DO - 10.1016/j.tig.2014.01.002 ID - Eissenberg2014 ER - TY - JOUR AU - Schwartzentruber, J. PY - 2012 DA - 2012// TI - Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma JO - Nature VL - 482 UR - https://doi.org/10.1038/nature10833 DO - 10.1038/nature10833 ID - Schwartzentruber2012 ER - TY - JOUR AU - Brower-Toland, B. AU - Riddle, N. C. AU - Jiang, H. AU - Huisinga, K. L. AU - Elgin, S. C. R. PY - 2009 DA - 2009// TI - Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster JO - Genetics VL - 181 UR - https://doi.org/10.1534/genetics.108.100271 DO - 10.1534/genetics.108.100271 ID - Brower-Toland2009 ER - TY - JOUR AU - Valadez-Graham, V. PY - 2012 DA - 2012// TI - XNP/dATRX interacts with DREF in the chromatin to regulate gene expression JO - Nucleic Acids Res VL - 40 UR - https://doi.org/10.1093/nar/gkr865 DO - 10.1093/nar/gkr865 ID - Valadez-Graham2012 ER - TY - BOOK AU - Bassett, A. R. AU - Cooper, S. E. AU - Ragab, A. AU - Travers, A. A. PY - 2008 DA - 2008// TI - The Chromatin Remodelling Factor dATRX Is Involved in Heterochromatin Formation ID - Bassett2008 ER - TY - JOUR AU - Emelyanov, A. V. AU - Konev, A. Y. AU - Vershilova, E. AU - Fyodorov, D. V. PY - 2010 DA - 2010// TI - Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M109.064790 DO - 10.1074/jbc.M109.064790 ID - Emelyanov2010 ER - TY - JOUR AU - Hong, Y. K. PY - 2009 DA - 2009// TI - dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons JO - Biochem Biophys Res Commun VL - 384 UR - https://doi.org/10.1016/j.bbrc.2009.04.112 DO - 10.1016/j.bbrc.2009.04.112 ID - Hong2009 ER - TY - BOOK AU - Xu, N. AU - Emelyanov, A. V. AU - Fyodorov, D. V. AU - Skoultchi, A. I. PY - 2014 DA - 2014// TI - Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling ID - Xu2014 ER - TY - JOUR AU - Shi, S. PY - 2008 DA - 2008// TI - Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability JO - Nat Cell Biol VL - 10 UR - https://doi.org/10.1038/ncb1713 DO - 10.1038/ncb1713 ID - Shi2008 ER - TY - JOUR AU - Ahmed-de-Prado, S. AU - Diaz-Garcia, S. AU - Baonza, A. PY - 2018 DA - 2018// TI - JNK and JAK/STAT signalling are required for inducing loss of cell fate specification during imaginal wing discs regeneration in Drosophila melanogaster JO - Dev Biol VL - 441 UR - https://doi.org/10.1016/j.ydbio.2018.05.021 DO - 10.1016/j.ydbio.2018.05.021 ID - Ahmed-de-Prado2018 ER - TY - JOUR AU - Pencik, J. PY - 2016 DA - 2016// TI - JAK-STAT signaling in cancer: from cytokines to non-coding genome JO - Cytokine VL - 87 UR - https://doi.org/10.1016/j.cyto.2016.06.017 DO - 10.1016/j.cyto.2016.06.017 ID - Pencik2016 ER - TY - JOUR AU - Penke, T. J. R. AU - McKay, D. J. AU - Strahl, B. D. AU - Gregory Matera, A. AU - Duronio, R. J. PY - 2018 DA - 2018// TI - Functional redundancy of variant and canonical histone H3 lysine 9 modification in drosophila JO - Genetics VL - 208 UR - https://doi.org/10.1534/genetics.117.300480 DO - 10.1534/genetics.117.300480 ID - Penke2018 ER - TY - JOUR AU - Udugama, M. PY - 2015 DA - 2015// TI - Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres JO - Nucleic Acids Res VL - 43 ID - Udugama2015 ER - TY - JOUR PY - 2017 DA - 2017// TI - The Drosophila DAXX-like protein (DLP) cooperates with ASF1 for H3.3 deposition and heterochromatin formation JO - Mol Cell Biol VL - 37 ID - ref51 ER - TY - JOUR AU - Zhang, R. PY - 2005 DA - 2005// TI - Formation of macroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA JO - Dev Cell VL - 8 UR - https://doi.org/10.1016/j.devcel.2004.10.019 DO - 10.1016/j.devcel.2004.10.019 ID - Zhang2005 ER - TY - STD TI - Zhu Q, et al. BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011;477(7363):179–84. ID - ref53 ER - TY - STD TI - Larson AG, et al. Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin. Nature. 2017;547(7662):236–40. ID - ref54 ER - TY - STD TI - Strom AR, Emelyanov AV, Mir M, Fyodorov DV, Darzacq X, Karpen GH. Phase separation drives heterochromatin domain formation. Nature. 2017;547(7662):241–5. ID - ref55 ER - TY - STD TI - Elmallah MIY, Cordonnier M, Vautrot V. Membrane-anchored heat-shock protein 70 ( Hsp70 ) in cancer. Cancer Lett. 2020;469:134–41. ID - ref56 ER - TY - JOUR AU - Tang, P. AU - Frankenberg, S. AU - Argentaro, A. AU - Graves, J. M. AU - Familari, M. PY - 2011 DA - 2011// TI - Comparative analysis of the ATRX promoter and 5′ regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alpha-globin regulation and testicular function JO - BMC Res. Notes VL - 4 UR - https://doi.org/10.1186/1756-0500-4-200 DO - 10.1186/1756-0500-4-200 ID - Tang2011 ER - TY - JOUR AU - Grossman, R. L. PY - 2016 DA - 2016// TI - Toward a shared vision for Cancer genomic data JO - N Engl J Med VL - 375 UR - https://doi.org/10.1056/NEJMp1607591 DO - 10.1056/NEJMp1607591 ID - Grossman2016 ER - TY - JOUR AU - Brand, A. H. AU - Perrimon, N. PY - 1993 DA - 1993// TI - Targeted gene expression as a means of altering cell fates and generating dominant phenotypes JO - Development VL - 118 ID - Brand1993 ER - TY - JOUR AU - Johansen, K. M. PY - 2009 DA - 2009// TI - Polytene chromosome squash methods for studying transcription and epigenetic chromatin modification in Drosophila using antibodies JO - Methods VL - 48 UR - https://doi.org/10.1016/j.ymeth.2009.02.019 DO - 10.1016/j.ymeth.2009.02.019 ID - Johansen2009 ER - TY - JOUR AU - Reynaud, E. AU - Lomeli, H. AU - Vazquez, M. AU - Zurita, M. PY - 1999 DA - 1999// TI - The Drosophila melanogaster homologue of the Xeroderma Pigmentosum D gene product is located in Euchromatic regions and has a dynamic response to UV light-induced lesions in Polytene chromosomes JO - Mol Biol Cell VL - 10 UR - https://doi.org/10.1091/mbc.10.4.1191 DO - 10.1091/mbc.10.4.1191 ID - Reynaud1999 ER - TY - JOUR AU - Schmittgen, T. D. AU - Livak, K. J. PY - 2008 DA - 2008// TI - Analyzing real-time PCR data by the comparative CT method JO - Nat Protoc VL - 3 UR - https://doi.org/10.1038/nprot.2008.73 DO - 10.1038/nprot.2008.73 ID - Schmittgen2008 ER - TY - JOUR AU - Langmead, B. AU - Salzberg, S. L. PY - 2012 DA - 2012// TI - Fast gapped-read alignment with bowtie 2 JO - Nat Methods VL - 9 UR - https://doi.org/10.1038/nmeth.1923 DO - 10.1038/nmeth.1923 ID - Langmead2012 ER - TY - JOUR AU - Li, H. PY - 2009 DA - 2009// TI - The sequence alignment/map format and SAMtools JO - Bioinformatics VL - 25 UR - https://doi.org/10.1093/bioinformatics/btp352 DO - 10.1093/bioinformatics/btp352 ID - Li2009 ER - TY - JOUR AU - Zhang, Y. PY - 2008 DA - 2008// TI - Model-based analysis of ChIP-Seq (MACS) JO - Genome Biol VL - 9 UR - https://doi.org/10.1186/gb-2008-9-9-r137 DO - 10.1186/gb-2008-9-9-r137 ID - Zhang2008 ER - TY - JOUR AU - Quinlan, A. R. AU - Hall, I. M. PY - 2010 DA - 2010// TI - BEDTools: a flexible suite of utilities for comparing genomic features JO - Bioinformatics VL - 26 UR - https://doi.org/10.1093/bioinformatics/btq033 DO - 10.1093/bioinformatics/btq033 ID - Quinlan2010 ER - TY - JOUR AU - Robinson, J. T. PY - 2011 DA - 2011// TI - Integrative genomics viewer JO - Nat Biotechnol VL - 29 UR - https://doi.org/10.1038/nbt.1754 DO - 10.1038/nbt.1754 ID - Robinson2011 ER -