Fig. 1

TSA alleviates apoptosis, oxidative stress, and MMP loss induced by H/R. a Apoptosis of cardiomyocytes was evaluated using Annexin/VI-PI staining under different dose of TSA treatment. b, c MDA and LDH amount in cardiomyocytes were analysed using commercial kit. d The ROS of cardiomyocytes was detected using commercial kit and flow cytometry. e JC-1 staining was used to evaluate the MMP. f Western blot was carried out to detect the apoptotic protein expression such as bax, cytoplasma cyt-c, cleaved caspase3, and bcl-2. *p < 0.05