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Fig. 7 | BMC Molecular and Cell Biology

Fig. 7

From: PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease

Fig. 7

PGRMC1 phosphorylation mutants elicit distinct patterns of genomic methylation. a Hierarchical clustering of methylation data from all cell lines sampled in triplicate. Clustering was applied using 520,031 probes with a coefficient of variation > 0.10. Height is calculated using the UPGMA method in the Lumi package and equates to the average distance between two members of two groups. b Volcano plots of the WT/MP, DM/WT and TM/DM comparisons. The log2 fold change (FC) (x axis) is plotted relative to the log10 p-value (y axis) to visualize the magnitude of the most significant features. Probes with an adjusted p-value < 0.05 and absolute log FC > 1 are plotted in green. Probes with an absolute logFC > 1 that were not significant are plotted in orange. Probes with a logFC < 1 that were significant at adjusted p-value < 0.05 are plotted in blue. Black probes were not significant. c Significant probes in each differential methylation comparison were extracted and the fraction of hypermethylated or hypomethylated probes per chromosome calculated. Methylation levels are higher in TM cells across all chromosomes

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