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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Diazoxide affects mitochondrial bioenergetics by the opening of mKATP channel on submicromolar scale

Fig. 1

The effect of diazoxide (DZ) on state 4 respiration in rat liver mitochondria in the absence and the presence of MgATP. a – Respiration rates in K+- and Na+-based media against DZ concentration, lg [M]; b – normalized respiration rates in the absence (native mitochondria) and the presence of Mg∙ATP; c – respiration rate differences in K+- and Na+-based media sensitive to the addition of Mg∙ATP and Mg2+ in the absence and the presence of 0.5 μM DZ; d – respiration rate differences in the presence of Mg∙ATP sensitive to the addition of DZ, glibenclamide and 5-HD. Additions are shown in the legends. M ± m, n = 9. c, d: * - P < 0.05 vs. MgATP, 0 DZ; ** - P < 0.01 vs. Mg2+; # - P < 0.01 vs. MgATP, 30 μM DZ

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