Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines

Jeremiasse, Bernadette; Matta, Csaba; Fellows, Christopher R.; Boocock, David J.; Smith, Julia R.; Liddell, Susan; Lafeber, Floris; van Spil, Willem E.; Mobasheri, Ali

doi:10.1186/s12860-020-00288-9

BMC Molecular and Cell Biology

Table 2 Results of an overrepresentation analysis on the identified proteins in unstimulated equine articular chondrocytes carried out using the Reactome resource. The analysis is based on a statistical (hypergeometric distribution) test that determines whether certain Reactome pathways are over-represented (enriched) in the submitted data. This test produces a probability score, which is corrected for false discovery rate using the Benjamani-Hochberg method. The 25 most relevant pathways sorted by p-value are shown. Table extracted from Reactome Pathway Analysis Report

From: Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines

Pathway name	Entities				Reactions
Pathway name	found	ratio	p-value	FDR^a	found	ratio
Neutrophil degranulation	66 / 480	0.033	1.11e-16	1.51e-13	10 / 10	8.01e-04
Formation of the cornified envelope	33 / 138	0.01	7.77e-16	5.29e-13	11 / 27	0.002
Extracellular matrix organization	47 / 329	0.023	1.37e-13	6.24e-11	181 / 318	0.025
Integrin cell surface interactions	21 / 86	0.006	1.02e-10	3.47e-08	46 / 54	0.004
Axon guidance	59 / 584	0.04	1.33e-10	3.61e-08	182 / 297	0.024
Keratinization	33 / 226	0.016	3.80e-10	8.64e-08	18 / 34	0.003
Developmental Biology	92 / 1207	0.084	2.00e-09	3.88e-07	206 / 511	0.041
Platelet degranulation	24 / 137	0.009	3.30e-09	5.61e-07	8 / 11	8.81e-04
Response to elevated platelet cytosolic Ca2+	24 / 144	0.01	8.45e-09	1.28e-06	8 / 14	0.001
Platelet activation, signaling and aggregation	35 / 293	0.02	1.76e-08	2.40e-06	42 / 114	0.009
Interleukin-12 family signaling	18 / 96	0.007	1.13e-07	1.39e-05	33 / 114	0.009
EPH-Ephrin signaling	18 / 101	0.007	2.35e-07	2.66e-05	52 / 56	0.004
Innate Immune System	91 / 1328	0.092	3.22e-07	3.35e-05	174 / 696	0.056
Cell junction organization	17 / 94	0.007	4.15e-07	4.02e-05	26 / 37	0.003
Signaling by Receptor Tyrosine Kinases	48 / 554	0.038	6.84e-07	6.03e-05	261 / 657	0.053
Cell-Cell communication	20 / 133	0.009	7.12e-07	6.03e-05	36 / 60	0.005
Hemostasis	63 / 821	0.057	7.54e-07	6.03e-05	83 / 327	0.026
Non-integrin membrane-ECM interactions	13 / 61	0.004	1.64e-06	1.23e-04	16 / 22	0.002
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	14 / 73	0.005	2.21e-06	1.56e-04	7 / 36	0.003
Interleukin-12 signaling	15 / 84	0.006	2.29e-06	1.56e-04	9 / 56	0.004
EPH-ephrin mediated repulsion of cells	12 / 55	0.004	3.23e-06	2.06e-04	9 / 9	7.21e-04
Syndecan interactions	9 / 29	0.002	3.47e-06	2.06e-04	9 / 15	0.001
Degradation of the extracellular matrix	20 / 148	0.01	3.49e-06	2.06e-04	53 / 105	0.008
Immune System	156 / 2822	0.196	7.43e-06	4.16e-04	344 / 1597	0.128
L1CAM interactions	18 / 130	0.009	7.70e-06	4.16e-04	21 / 54	0.004

^aFalse Discovery Rate

Back to article page

ISSN: 2661-8850

Contact us

General enquiries: journalsubmissions@springernature.com