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Table 2 Results of an overrepresentation analysis on the identified proteins in unstimulated equine articular chondrocytes carried out using the Reactome resource. The analysis is based on a statistical (hypergeometric distribution) test that determines whether certain Reactome pathways are over-represented (enriched) in the submitted data. This test produces a probability score, which is corrected for false discovery rate using the Benjamani-Hochberg method. The 25 most relevant pathways sorted by p-value are shown. Table extracted from Reactome Pathway Analysis Report

From: Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines

Pathway nameEntitiesReactions
foundratiop-valueFDRafoundratio
Neutrophil degranulation66 / 4800.0331.11e-161.51e-1310 / 108.01e-04
Formation of the cornified envelope33 / 1380.017.77e-165.29e-1311 / 270.002
Extracellular matrix organization47 / 3290.0231.37e-136.24e-11181 / 3180.025
Integrin cell surface interactions21 / 860.0061.02e-103.47e-0846 / 540.004
Axon guidance59 / 5840.041.33e-103.61e-08182 / 2970.024
Keratinization33 / 2260.0163.80e-108.64e-0818 / 340.003
Developmental Biology92 / 12070.0842.00e-093.88e-07206 / 5110.041
Platelet degranulation24 / 1370.0093.30e-095.61e-078 / 118.81e-04
Response to elevated platelet cytosolic Ca2+24 / 1440.018.45e-091.28e-068 / 140.001
Platelet activation, signaling and aggregation35 / 2930.021.76e-082.40e-0642 / 1140.009
Interleukin-12 family signaling18 / 960.0071.13e-071.39e-0533 / 1140.009
EPH-Ephrin signaling18 / 1010.0072.35e-072.66e-0552 / 560.004
Innate Immune System91 / 13280.0923.22e-073.35e-05174 / 6960.056
Cell junction organization17 / 940.0074.15e-074.02e-0526 / 370.003
Signaling by Receptor Tyrosine Kinases48 / 5540.0386.84e-076.03e-05261 / 6570.053
Cell-Cell communication20 / 1330.0097.12e-076.03e-0536 / 600.005
Hemostasis63 / 8210.0577.54e-076.03e-0583 / 3270.026
Non-integrin membrane-ECM interactions13 / 610.0041.64e-061.23e-0416 / 220.002
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation14 / 730.0052.21e-061.56e-047 / 360.003
Interleukin-12 signaling15 / 840.0062.29e-061.56e-049 / 560.004
EPH-ephrin mediated repulsion of cells12 / 550.0043.23e-062.06e-049 / 97.21e-04
Syndecan interactions9 / 290.0023.47e-062.06e-049 / 150.001
Degradation of the extracellular matrix20 / 1480.013.49e-062.06e-0453 / 1050.008
Immune System156 / 28220.1967.43e-064.16e-04344 / 15970.128
L1CAM interactions18 / 1300.0097.70e-064.16e-0421 / 540.004
  1. aFalse Discovery Rate