Skip to main content

Table 3 Results of an overrepresentation analysis on the identified proteins following cytokine stimulation in equine articular chondrocytes carried out using the Reactome resource. The analysis is based on a statistical (hypergeometric distribution) test that determines whether certain Reactome pathways are over-represented (enriched) in the submitted data. This test produces a probability score, which is corrected for false discovery rate using the Benjamani-Hochberg method. The 25 most relevant pathways sorted by p-value are shown. Table extracted from Reactome Pathway Analysis Report

From: Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines

Pathway nameEntitiesReactions
foundratiop-valueFDRafoundratio
Neutrophil degranulation56 / 4800.0331.11e-161.27e-1310 / 108.01e-04
Formation of the cornified envelope28 / 1380.011.94e-141.11e-1113 / 270.002
Extracellular matrix organization42 / 3290.0234.09e-141.56e-11183 / 3180.025
RAB geranylgeranylation18 / 680.0051.39e-113.99e-092 / 54.00e-04
Integrin cell surface interactions18 / 860.0065.71e-101.31e-0745 / 540.004
Keratinization28 / 2260.0161.55e-092.97e-0720 / 340.003
Non-integrin membrane-ECM interactions15 / 610.0041.88e-093.06e-0719 / 220.002
Platelet degranulation21 / 1370.0095.09e-097.28e-078 / 118.81e-04
Response to elevated platelet cytosolic Ca2+21 / 1440.011.19e-081.51e-068 / 140.001
Cell-Cell communication20 / 1330.0091.61e-081.84e-0646 / 600.005
Syndecan interactions10 / 290.0024.43e-084.61e-0612 / 150.001
Axon guidance45 / 5840.044.92e-084.67e-06147 / 2970.024
Developmental Biology73 / 12070.0846.41e-085.64e-06167 / 5110.041
Post-translational protein phosphorylation17 / 1090.0081.16e-079.37e-061 / 18.01e-05
Cell junction organization15 / 940.0074.83e-073.67e-0526 / 370.003
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)17 / 1270.0099.31e-076.61e-051 / 140.001
Transport of small molecules58 / 9630.0671.97e-061.32e-0497 / 4380.035
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA6 / 139.01e-044.45e-062.80e-042 / 32.40e-04
ATF6 (ATF6-alpha) activates chaperone genes6 / 150.0019.96e-065.98e-043 / 54.00e-04
Vesicle-mediated transport49 / 8240.0571.83e-050.001115 / 2510.02
Adherens junctions interactions8 / 350.0021.93e-050.00116 / 160.001
ATF6 (ATF6-alpha) activates chaperones6 / 170.0012.00e-050.0014 / 108.01e-04
Transport of inorganic cations/anions and amino acids/oligopeptides17 / 1650.0112.71e-050.00123 / 750.006
Platelet activation, signaling and aggregation24 / 2930.022.78e-050.00133 / 1140.009
Innate Immune System69 / 13280.0922.80e-050.00188 / 6960.056
  1. aFalse Discovery Rate