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Fig. 1 | BMC Molecular and Cell Biology

Fig. 1

From: Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

Fig. 1

Presentation of drug-resistant mutants. a List of the 30 drug-resistant mutants with their different mutations. b Localization of the mutations observed in the 30 drug-resistant mutants onto the 3D structure of wild-type PR2. PR2 is displayed in cartoon mode and colored according to the 13 extracted PR2 regions defined in [32, 37, 38]. Each PR2 region is colored as follows: the Nter and Cter regions in grey, the R1 region in dark blue, the fulcrum region in green, the catalytic region in purple, the R2 region in orange, the elbow region in blue, the flap region in magenta, the cantilever region in yellow, the R3 region in pink, the wall region in cyan, the R4 region in brown, and the α-helix region in red. Positions, where drug-resistance mutations occur, are displayed in stick mode. c Limits of the 13 structural and functional regions extracted from PR2. The 20 pocket residues were highlighted in red

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