Fig. 2
From: Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease
Localization of asymmetric and symmetric positions in the wild-type and mutant structure. a 3EBZmini structure colored according to residue asymmetric behavior in the three wild-type structures: the 51 residues that are symmetric in the three 3EBZmini structures are colored blue, the 27 residues asymmetric in the three 3EBZmini structures are colored red, and the 18 residues exhibiting different asymmetric statuses in the three 3EBZmini structures are colored yellow. b 3EBZmini structure colored according to residue asymmetric status in the mutant set: the 25 residues that are symmetric in the 150 mutants are blue, the 25 residues that are overrepresented in terms of asymmetry in the mutant set and are asymmetric in the three 3EBZmini structures are red, the 11 residues that are overrepresented in terms of asymmetry in the mutant set and are symmetric in the three 3EBZmini structures are orange, and the 2 residues that are asymmetric in the three 3EBZmini structures and are not overrepresented in the mutant set are yellow. Additional file 2: Figure S2 lists the positions of each type in the wild-type and mutant sets and their distributions in the 13 regions