Fig. 3

Network summarizing the link between the 30 drug-resistant mutants and changes in asymmetry. In this network, white square nodes correspond to mutants, and colored nodes (square and circle) correspond to positions where a change in asymmetry occurs. Positions are colored according to the 13 regions extracted from the PR2 structure. See Fig. 1b for the region color legend. The shape of position nodes indicates the type of change in asymmetry occurring at the studied position: the circular nodes indicate asymmetry and the square nodes indicate the loss of asymmetry. This network connects a mutant to a position if the position presents a change in asymmetry in at least one of its five structures. The edge thickness is proportional to the number of mutant structures exhibiting the change (ranging from 1 to 5). The edges are colored according to whether the change in asymmetry occurred at a position located in the binding pocket (in red) or outside of the binding pocket (in gray)