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Table 1 Effects of MTX on the oocyte fertilization and the fertilized embryo formation

From: Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms

  Fertilization rate (%) 2-cell rate (%) 8-cell rate (%) Blastocyst rate (%) No. of ICM; No. of total cells; ratio (%)
Control group (total number of oocytes, No.168) 81.5 ± 2.1 76.7 ± 1.8 59.4 ± 2.5 48.8 ± 3.1 14.6 ± 1. 7
46.1 ± 2.2
31.7 ± 4.0
MTX group (No.124) 59.9 ± 3.7* 46.9 ± 2.2* 29.9 ± 2.1* 21.2 ± 3.3* 11.5 ± 1.9*
45.5 ± 2.0
25.8 ± 3.9*
  1. * p < 0.05, There is significant difference between the MTX and control groups