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Table 1 Effects of MTX on the oocyte fertilization and the fertilized embryo formation

From: Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms

 

Fertilization rate (%)

2-cell rate (%)

8-cell rate (%)

Blastocyst rate (%)

No. of ICM; No. of total cells; ratio (%)

Control group (total number of oocytes, No.168)

81.5 ± 2.1

76.7 ± 1.8

59.4 ± 2.5

48.8 ± 3.1

14.6 ± 1. 7

46.1 ± 2.2

31.7 ± 4.0

MTX group (No.124)

59.9 ± 3.7*

46.9 ± 2.2*

29.9 ± 2.1*

21.2 ± 3.3*

11.5 ± 1.9*

45.5 ± 2.0

25.8 ± 3.9*

  1. * p < 0.05, There is significant difference between the MTX and control groups