Fig. 4
From: Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro
Reduced OLA1 expression is related to paclitaxel-induced cancer cell metastasis. a The OLA1 expression in UM-1 cell treated with 100 nM PTX for 0–8 days. b and c Cell viability assay showed that OLA1 overexpression enhanced the PTX sensitivity in UM-1 cells (n = 3). d Cell flow cytometry was used to determine the effect of overexpression of OLA1 on paclitaxel-induced (20 μM) cell necrosis and apoptosis (n = 2). e Cell flow cytometry showed the effect of OLA1 on paclitaxel-induced (20 μM) cell necrosis and apoptosis through SMAD2 (n = 2). f Mechanism of OLA1 inhibits metastasis of OSCC. vs. Control, *P < 0.05, **P < 0.01, ***P < 0.001