Fig. 3

Kinetic patterns of cooperative gene expression in SF. SF were cultured in the presence or absence of TNFα (10 ng/ml), IL6/sIL6R (50 ng/ml each) or both. a Representative genes IL6, CCL2, IL8/CXCL8, CCL8, and MMP1 mRNA expression of four to six independent cultures. b IL8/CXCL8 and CCL8 protein in supernatants of six independent SF cultures. Values are mean ± SEM (vs control, *2way ANOVA with Fisher’s LSD multiple comparisons test)