Fig. 4From: IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanismsStability of mRNA encoded by early and late genes. SF were stimulated for 24 h with either IL6/sIL6R (50 ng/ml each) (a), TNFα (10 ng/ml) (b), or both (c). Change of IL6, CCL2, IL8/CXCL8, CCL8, MMP1 and MMP3 mRNA expression are relative to the baseline value before the addition of actinomycin D (ActD) (0 h). Data are the mean of three independent experimentsBack to article page