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Fig. 3 | BMC Molecular and Cell Biology

Fig. 3

From: Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes

Fig. 3

The effect of sclerostin inhibition on osteocyte induced osteoclastogenesis in a co-culture system. a Images show TRAP+ osteoclasts (orange arrows) formed when BMM cells were co-cultured with OCY454 cells for 6 days. (N = 3, n = 9). Quantification of images showing (b) percentage area covered by the TRAP+ cells (N = 3, n = 9) and c TRAP activity in supernatant collected from OCY454-BMM co-cultures after 6 days (N = 3, n = 9). E, estrogen treatment; ED, Estrogen deficient; Scl-Ab, Sclerostin antibody. Student’s t-test. * = p < 0.05 and **** = p < 0.0001

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