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Fig. 4 | BMC Molecular and Cell Biology

Fig. 4

From: Role of tumor cell senescence in non-professional phagocytosis and cell-in-cell structure formation

Fig. 4

Representative microscopic images of typical cell-in-cell structures in phagocytosis experiments with (a, d) pancreas carcinoma cell line (BxPC-3) and fibroblast cell lines (b, e) (SBLF-7) and (c, f) (SBLF-4). Viable CTOG-stained (green) cell, which completely encloses a hyperthermia-damaged, CTFR-stained (red) cell (a-c). Senescent H3K9me3-stained (red) cells that completely enclose a hyperthermia-damaged CTOG-stained (green) cell (d-f). Cell nuclei were stained with DAPI (blue). Scale bars 10 μm (40x objective). In bar charts (g), (h) and (j) the cell-in-cell rates occurring in the respective cell lines on the left were shown for different combinations of senescent, living and heat-treated dead cells as indicated

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